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ARPA-H Launches SURPASS to Advance Simulation-Augmented, Real-Time Adaptive Clinical Trials

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The Advanced Research Projects Agency for Health’s (ARPA-H) Proactive Health Office has released Innovative Solutions Opening (ISO) ARPA-H SOL 26 164 for the Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS) program. SURPASS seeks to establish persistent, multi-arm clinical trial platforms that integrate simulation, accumulating human data, prespecified adaptations, shared operational infrastructure, and reusable regulatory assets.

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BARDA’s “Protection Before Day One” Initiative Seeks Broadly Protective Influenza Vaccines

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The Biomedical Advanced Research and Development Authority (BARDA), through the Rapid Response Partnership Vehicle (RRPV), has released a draft Request for Project Proposals (RPP) for “Protection Before Day One” (PBD1), Solicitation No. RRPV 26-08-PBD1. The initiative seeks to close a central pandemic preparedness gap: the time between identifying a novel pandemic influenza strain and deploying

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DARPA APM Solicitation Opens for Programmable Precision Polymers

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The Defense Advanced Research Projects Agency’s (DARPA) Multi X Office has released the official solicitation for Atomically Precise Molecules (APM), seeking new polymer synthesis approaches that can deliver precisely controlled materials with breakthrough nonlinear optical performance. Required proposal abstracts are due October 27, 2026, at 1:00 p.m. ET, with full proposals due December 18, 2026,

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BARDA BioMaP Seeks Agile, Distributed Drug Manufacturing for Medical Countermeasures

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The Biomedical Advanced Research and Development Authority (BARDA) has released has released a Request for Project Proposals through Biopharmaceutical Manufacturing Preparedness Consortium (BioMaP), seeking U.S.-based teams that can develop and commercialize agile, distributed manufacturing capacity for medical countermeasures. RPP 26-13-EDM focuses on end-to-end production of small-molecule drug substances and finished drug products, from key starting

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ARPA-H Launches SPECTRA Program to Advance Autism Research, Precision Care, and Quality of Life

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The Advanced Research Projects Agency for Health (ARPA-H) has released the Systems for Phenotypic Evaluation, Clinical Trajectories, Response, and Agency (SPECTRA) solicitation, a new Proactive Health Office program focused on improving how autism is understood, assessed, and supported across the lifespan. SPECTRA seeks multidisciplinary research and development efforts that can identify individual developmental and health

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ARPA-H COSMOS Initiative Seeks to Test Whether Space Can Accelerate Regenerative Drug Development

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The Advanced Research Projects Agency for Health (ARPA-H) has released ARPA-H-SOL-26-165, an Innovative Solutions Opening (ISO) for Comprehensive Organ System Modeling in Outer Space (COSMOS). The program will test a consequential hypothesis for the emerging low Earth orbit (LEO) bioeconomy: whether microgravity accelerates aging-related changes in human tissues quickly enough to make autonomous, space based

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ARPA-H UNIQUE: Advancing Quantum Derived Biomedical Imaging

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The Advanced Research Projects Agency for Health (ARPA-H) has released Innovative Solutions Opening (ISO), UNifying Imaging with QUantum Entanglement* (UNIQUE). The program seeks to determine whether quantum derived observables from 511 keV photon pairs including quantum correlations, correlation loss or decoherence, and positronium sensitive interactions that can provide biologically meaningful imaging contrast beyond the anatomical,

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A Closer Look at the NIH and DoW Medical Countermeasure Agreement

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Earlier this month, on September 4, the The National Institutes of Health (NIH) and the United States Department of War (DoW) released a 10-year interagency agreement (IAA) supporting the advanced development of medical countermeasures for pandemic influenza, chemical, biological, radiological, and nuclear threats, and emerging infectious diseases. The agreement brings NIH’s scientific data, product pipelines,

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ARPA-H Launches Emerging Health Innovators Initiative for Early-Career Researchers

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The Advanced Research Projects Agency for Health is preparing to launch the Emerging Health Innovators (EHI) Initiative, a new annual funding pathway designed to bring early-career investigators into the ARPA-H innovation model. The upcoming opportunity is intended for researchers and innovators with bold ideas to address healthcare gaps in the United States, including those who

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BARDA's Growing Use of Hubs and Prize Competitions, Beyond SAM.gov

BARDA’s Growing Use of Hubs and Prize Competitions, Beyond SAM.gov

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If you’ve been tracking Biomedical Advanced Research and Development Authority (BARDA) activity solely through SAM.gov, some opportunities may be easy to miss. Yes, traditional funding and contracting mechanisms, like BAAs and RFPs, continue to be pushed by BARDA – and will continue to do so for some time – but the agency is also making

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DARPA Announces HUBBLE Proposers Day to Map the Human Interactome

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The Defense Advanced Research Projects Agency (DARPA), through its Biological Technologies Office (BTO), has issued Special Notice DARPA-SN-26-121 announcing a Proposers Day for the planned “High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators” (HUBBLE) program. HUBBLE targets one of the most consequential unsolved problems in computational biology: building an in-silico capability to map all

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Four Takeaways from the 2026 RRPV General Membership Meeting

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The Rapid Response Partnership Vehicle (RRPV) consortium, through the Biomedical Advanced Research and Development Authority (BARDA), convenes government, industry, academic, nonprofit, and service-provider organizations working to accelerate medical countermeasures for emerging infectious diseases and other national preparedness priorities. EverGlade team members Laura Powell, PhD, PMP, and Richard Merlino, MBA attended last week’s General Membership Meeting

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