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ARPA-H

ARPA-H’s THEA Program Seeks Breakthrough Optic Nerve Imaging Technologies

Download the Solicitation The Advanced Research Projects Agency for Health (ARPA-H), through its Health Science Futures Mission Office, has released a Sources Sought notice titled “Novel and Enhanced Modalities for Optic Nerve Imaging” (ARPA-H-SS-26-157). This request is being issued in support of ARPA-H’s Transplantation of Human Eye Allografts (THEA) program, an ambitious initiative focused on […]

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ARPA-H’s HEARING Program Aims to Revolutionize Brain-Driven Hearing Restoration

The Advanced Research Projects Agency for Health (ARPA-H), through its Health Science Futures (HSF) Office, has released an Innovative Solutions Opening (ISO) for Hearing Enhancement through ARtificially Intelligent NeurotechnoloGy (HEARING), ARPA-H-SOL-26-154. The program seeks to fundamentally rethink hearing loss treatment by shifting the focus from the ear alone to the brain’s auditory cortex. ARPA-H estimates

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ARPA-H Launches IGoR Program to Transform Biomedical Research Infrastructure

ARPA-H Launches IGoR Program to Transform Biomedical Research Infrastructure

ARPA-H-SOL-26-155 APPENDIX A: PROGRAM AND TECHNICAL DESCRIPTION The Advanced Research Projects Agency for Health (ARPA-H) has released the Intelligent Generator of Research (IGoR) Innovative Solutions Opening (ISO), a bold initiative designed to fundamentally transform how biomedical research is conducted. Managed through ARPA-H’s Proactive Health Office, the program seeks to address longstanding inefficiencies in scientific discovery

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ARPA-H TIGAR Biopreservation

ARPA-H TIGAR Opens a New Lane for Biopreservation Innovation

ARPA-H-SOL-26-144_TIGAR ISO ARPA-H’s new Technology InteGrator and AcceleratoR (TIGAR) Innovative Solutions Opening (ISO) is a tightly scoped opportunity for government contractors and their research partners to reshape how complex biologics, tissues, and organs are stored, transported, and deployed at scale. By seeding high-risk, high-impact biopreservation concepts, TIGAR aims to unlock temperature-flexible storage for increasingly large

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ARPA-H STOMP Program

ARPA-H STOMP Program: Advancing the Science of Microplastics and Human Health

STOMP_ISO_ARPA-H-SOL-26-152 The Advanced Research Projects Agency for Health (ARPA-H) has released an Innovative Solutions Opening (ISO) for the Systematic Targeting of Microplastics (STOMP) program, signaling a major federal investment in understanding and addressing the health impacts of micro- and nano-plastics (MNPs). As mounting evidence links MNP exposure to a range of adverse health outcomes, ARPA-H

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ARPA-H 1-CURE Initiative

ARPA-H’s 1-CURE Initiative to Revolutionize Universal Cancer Radiotherapy

1-CURE_ISO_ARPA-H-SOL-26-147 Cancer remains one of the leading causes of death globally, with existing treatment modalities often limited by cost, accessibility, and effectiveness, particularly for metastatic disease. In response, the Advanced Research Projects Agency for Health (ARPA-H) has released an Innovative Solutions Opening (ISO) under solicitation ARPA-H-SOL-26-147 for the One Comprehensive Universal Radiotherapy for Everyone (1-CURE)

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ARPA-H Delphi Program Draft Featured Image

ARPA-H’s Delphi Program Draft ISO Signals New Opportunities in Continuous Biosensing

ARPA-H-SOL-26-153+DRAFT+Delphi+ISO Overview of the DELPHI Program The Advanced Research Projects Agency for Health (ARPA-H) has released a Draft Innovative Solutions Opening (ISO) for the Delphi program through its Resilient Systems Office (RSO). The draft announcement, ARPA-H-SOL-26-153, is intended to inform the research community about an upcoming funding opportunity and allow potential performers time to prepare

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ARPA-H ADVOCATE Program

ARPA-H’s ADVOCATE Program: What Amendment 02 Means for Proposers

ADVOCATEISO_ARPA-H-SOL-26-142_Amendment02 The Advanced Research Projects Agency for Health (ARPA-H) released Amendment 02 to its ADVOCATE solicitation (ARPA-H-SOL-26-142), refining technical expectations, evaluation criteria, and program execution details for one of its most ambitious artificial intelligence initiatives in healthcare. ADVOCATE is designed to accelerate the development, evaluation, and scalable deployment of clinical artificial intelligence (AI) agents that

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ARPA-H CIRCLE Program

ARPA-H’s CIRCLE Program

ISO+Amd+1+-+CIRCLE The Advanced Research Projects Agency for Health (ARPA-H), through its Resilient Systems Office (RSO), has released an Innovative Solutions Opening (ISO) titled Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE), ARPA-H-SOL-26-139 . This solicitation reflects ARPA-H’s mandate to pursue bold, high-impact biomedical innovations that can transform patient outcomes at scale. With CIRCLE,

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ARPA-H BIOGAMI

ARPA-H Launches BIOGAMI to Transform Therapeutics for Protein Misfolding Diseases

BIOGAMI ISO ARPA-H-SOL-26-149 The Advanced Research Projects Agency for Health (ARPA-H) has released a new Innovative Solutions Opening (ISO) for the BIOmolecular Grammar for protein Aggregation Modulation and Intervention (BIOGAMI) program. Announced under ARPA-H-SOL-26-149, BIOGAMI reflects ARPA-H’s mission to pursue high-risk, high-reward research that can fundamentally transform health outcomes. The program is focused on addressing

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ARPA-H ADVOCATE Program

ARPA-H Launches ADVOCATE to Transform Cardiovascular Care with Agentic AI

ARPA-H-SOL-26-142_ADVOCATE+ISO ARPA-H Launches ADVOCATE to Transform Cardiovascular Care with Agentic AI The Advanced Research Projects Agency for Health (ARPA-H) has released a new Innovative Solutions Opening (ISO), Agentic AI-Enabled Cardiovascular Care Transformation (ADVOCATE), aimed at fundamentally modernizing how chronic cardiovascular disease (CVD) is managed in the United States. Announced by ARPA-H’s Scalable Solutions Office (SSO),

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ARPA-H BioStabilization Systems (BoSS) Program

ARPA-H Launches the BioStabilization Systems (BoSS) Program to Transform Cell Therapy Distribution

BOSS_ISO_Final_01Dec2025 The Advanced Research Projects Agency for Health (ARPA-H) has announced a landmark Innovative Solutions Opening (ISO) for the BioStabilization Systems (BoSS) program, an ambitious effort to revolutionize how live cell-based therapies are stabilized, manufactured, and distributed. As outlined in the solicitation, BoSS aims to eliminate the field’s dependence on ultra-cold storage and transport, which

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