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BARDA Seeks Input on “Protection Before Day One” Influenza Vaccines with Pandemic Coverage

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Download the RFI Overview of the RFI The Biomedical Advanced Research and Development Authority (BARDA), within the Administration for Strategic Preparedness and Response (ASPR), has released a Request for Information (RFI) titled “Protection Before Day One Vaccine: Advancing Broadly Protective Seasonal Influenza Vaccines with Pandemic Coverage.” Through this market research effort, BARDA is seeking feedback from industry, academia, and […]

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DARPA and NSF Launch AI Forge Initiative for University-Led National Security AI Research

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Download the Solicitation The Defense Advanced Research Projects Agency (DARPA), in partnership with the National Science Foundation (NSF) and the Center for AI Standards and Innovation (CAISI) at the National Institute of Standards and Technology (NIST), has released a Request for Information (RFI) for the AI Forge Program. This initiative seeks to identify the capabilities

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DARPA Releases TA1/TA2 Solicitation for RAPIID Blood Analog Systems for Far-Forward Trauma Care

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The Defense Advanced Research Projects Agency (DARPA), through its Biological Technologies Office (BTO), has released Program Solicitation DARPA-PS-26-124 for the Resuscitation and Prevention of Ischemia-Induced Dysfunction (RAPIID) program. RAPIID aims to develop a deployable blood analog system capable of providing the life-saving functions of stored whole blood without requiring cold-chain storage or donor logistics. This

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BARDA Seeks Input on Medical Countermeasures for Drug-Resistant Fungal Infections

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Download the Solicitation The Biomedical Advanced Research and Development Authority (BARDA), within the Administration for Strategic Preparedness and Response (ASPR) at the U.S. Department of Health and Human Services (HHS), has issued a Request for Information (RFI) to better understand the current development landscape for antifungal medical countermeasures. BARDA plays a central role in advancing

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BARDA Seeks Input on AI-Enabled Discovery of Broad-Spectrum Small-Molecule Filovirus Therapeutics

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Download the Solicitation The Biomedical Advanced Research and Development Authority (BARDA), part of the Administration for Strategic Preparedness and Response (ASPR) within the U.S. Department of Health and Human Services (HHS), has issued a Request for Information (RFI) focused on AI-Enabled Discovery of Broad-Spectrum Small-Molecule Inhibitors for Filoviruses. Filoviruses, including Ebola virus (EBOV), Sudan virus

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DARPA Seeks Input on Rapid Petroleum Stabilization and Repurposing Technologies

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Download the Solicitation The Defense Advanced Research Projects Agency (DARPA), through its Biological Technologies Office (BTO), has released a Request for Information (RFI) titled ROUNDTOP, seeking input from industry, academia, government laboratories, and non-traditional performers. The RFI focuses on advanced methods to rapidly stabilize and/or repurpose large volumes of petroleum products, including petroleum abandoned in

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DARPA Explores Universal Biomolecule Purification Platforms Through New MTO RFI

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Download the Solicitation The Defense Advanced Research Projects Agency (DARPA), through its Microsystems Technology Office (MTO), has released Request for Information (RFI) DARPA-SN-26-66 focused on biomolecule purification technologies. The RFI seeks information on novel purification methods capable of enabling a universal platform for separating and recovering multiple large and complex molecules from complex biological feedstocks

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ARPA-H’s THEA Program Seeks Breakthrough Optic Nerve Imaging Technologies

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Download the Solicitation The Advanced Research Projects Agency for Health (ARPA-H), through its Health Science Futures Mission Office, has released a Sources Sought notice titled “Novel and Enhanced Modalities for Optic Nerve Imaging” (ARPA-H-SS-26-157). This request is being issued in support of ARPA-H’s Transplantation of Human Eye Allografts (THEA) program, an ambitious initiative focused on

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ARPA-H’s HEARING Program Aims to Revolutionize Brain-Driven Hearing Restoration

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The Advanced Research Projects Agency for Health (ARPA-H), through its Health Science Futures (HSF) Office, has released an Innovative Solutions Opening (ISO) for Hearing Enhancement through ARtificially Intelligent NeurotechnoloGy (HEARING), ARPA-H-SOL-26-154. The program seeks to fundamentally rethink hearing loss treatment by shifting the focus from the ear alone to the brain’s auditory cortex. ARPA-H estimates

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autonomous robotic systems – Untethered Robotics

Materials for Physical Compute in Untethered Robotics

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DARPA-SN-26-76 In April 2026, the Defense Advanced Research Projects Agency (DARPA), through its Microsystems Technology Office (MTO), released a Request for Information (RFI) titled “Materials for Physical Compute in Untethered Robotics” (DARPA-SN-26-76). This RFI signals DARPA’s early-stage interest in advancing the next generation of autonomous robotic systems capable of operating in communication-denied and dynamically changing

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Organoid Cytomorphic Intelligence Resulting from Convergent Understanding and Information Transfer (O-Circuit)

DARPA’s O-Circuit Program and the Future of Biological Computing

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DARPA-PS-26-28 In May 2026, the Defense Advanced Research Projects Agency (DARPA), through its Biological Technologies Office (BTO), released a new program solicitation titled Organoid Cytomorphic Intelligence Resulting from Convergent Understanding and Information Transfer (O-Circuit). This initiative reflects DARPA’s continued investment in next-generation computing paradigms, specifically those that move beyond traditional silicon-based systems. At a high

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ARPA-H Launches IGoR Program to Transform Biomedical Research Infrastructure

ARPA-H Launches IGoR Program to Transform Biomedical Research Infrastructure

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ARPA-H-SOL-26-155 APPENDIX A: PROGRAM AND TECHNICAL DESCRIPTION The Advanced Research Projects Agency for Health (ARPA-H) has released the Intelligent Generator of Research (IGoR) Innovative Solutions Opening (ISO), a bold initiative designed to fundamentally transform how biomedical research is conducted. Managed through ARPA-H’s Proactive Health Office, the program seeks to address longstanding inefficiencies in scientific discovery

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