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DARPA APM Solicitation Opens for Programmable Precision Polymers

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The Defense Advanced Research Projects Agency’s (DARPA) Multi X Office has released the official solicitation for Atomically Precise Molecules (APM), seeking new polymer synthesis approaches that can deliver precisely controlled materials with breakthrough nonlinear optical performance. Required proposal abstracts are due October 27, 2026, at 1:00 p.m. ET, with full proposals due December 18, 2026,

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DARPA Firefox Seeks Scalable Technologies for High-Resolution, Noninvasive Brain-Computer Interface

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Download the Solicitation The Defense Advanced Research Projects Agency’s (DARPA) Biological Technologies Office (BTO) has released the Firefox Program Solicitation, DARPA-PS-26-137, to advance a scalable, noninvasive brain-computer interface (BCI). The program seeks to build on DARPA’s existing coherent optical sensing system by addressing two scale up barriers: steering coherent light across multiple neural sensing regions

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DARPA APM Program: Upcoming Opportunity to Advance Programmable Precision Polymers

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The Multi X Office of the Defense Advanced Research Projects Agency (DARPA) is preparing to launch the Atomically Precise Molecules (APM) program, an upcoming effort to develop new material-synthesis capabilities using programmable precision polymers, or PPPs. The program will initially demonstrate this capability through next-generation non-linear optical materials for electro-optic modulators, with potential relevance to

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DARPA Announces HUBBLE Proposers Day to Map the Human Interactome

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The Defense Advanced Research Projects Agency (DARPA), through its Biological Technologies Office (BTO), has issued Special Notice DARPA-SN-26-121 announcing a Proposers Day for the planned “High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators” (HUBBLE) program. HUBBLE targets one of the most consequential unsolved problems in computational biology: building an in-silico capability to map all

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DARPA Firefox Program to Explore High-Channel, Noninvasive Brain-Computer Interfaces

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The Defense Advanced Research Projects Agency (DARPA), through its Biological Technologies Office (BTO), is hosting a Firefox Proposers Day in support of a planned Firefox Program Solicitation. Firefox seeks to advance coherent optical technologies that could enable a scalable, noninvasive brain-computer interface, or BCI, with single-neuron spatiotemporal resolution. The Special Notice is not yet a

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DARPA Releases Official Solicitation for Protein ENGineering (PENG)

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The Defense Advanced Research Projects Agency (DARPA), under the Defense Sciences Office (DSO), has released the full Program Solicitation for Protein ENGineering (PENG), DARPA-PS-26-129. The solicitation moves PENG from concept and Proposers Day into an active, multi‑phase program seeking innovative proposals to build a multifunctional, target‑agnostic platform for precise, programmable editing of endogenous proteins. PENG’s

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DARPA Launches PINPOINT Program To Break The GPS Dependency

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The Defense Advanced Research Projects Agency (DARPA), under the Defense Sciences Office (DSO), has released a Broad Agency Announcement (BAA) for the Precision Inertial Navigation & Positioning On an Integrated Tesseract (PINPOINT) program, HR001126S0016. PINPOINT aims to deliver a new class of micro‑scale inertial measurement units (IMUs) that can provide GPS‑quality positioning and navigation over

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DARPA’s QBI Stage A: Stress‑Testing The Path To A Utility‑Scale Quantum Computer

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The Defense Advanced Research Projects Agency (DARPA)‘s Multi X Office has expanded the Quantum Benchmarking Initiative (QBI) with a new Topic call, QBIT Stage A, aimed at one deceptively simple question: can any quantum architecture credibly reach a utility‑scale, fault‑tolerant machine by about 2033. QBI defines “utility‑scale” as a quantum computer whose computational value exceeds its cost,

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DARPA Announces PENG Program for Programmable Protein Engineering

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The Defense Advanced Research Projects Agency (DARPA) has issued a Special Notice for a new Defense Sciences Office (DSO) program, Protein ENGineering (PENG), and is hosting a hybrid Proposers Day on August 10, 2026, in Arlington, VA, with a webcast option for virtual attendees. DARPA expects to publish the full program solicitation by the end

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DARPA’s Perrseus Program: Manufacturable µUHV for Quantum & Atomic Sensors

DARPA’s Perrseus Program: Manufacturable µUHV for Quantum & Atomic Sensors

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The Defense Advanced Research Projects Agency (DARPA) Perrseus program is now live with a formal solicitation, moving from concept to concrete timelines and technical expectations. The goal hasn’t changed: build manufacturable, microscale ultra‑high‑vacuum (µUHV) packages that can support next‑generation quantum, MEMS, and photonics‑based sensors without relying on room‑sized vacuum systems. With the solicitation out, teams

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New DARPA RFI: Multiscale Reasoning Across Human Physiology

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The Defense Advanced Research Projects Agency (DARPA), through its Biological Technologies Office (BTO), has released RFI DARPA‑SN‑26‑100 on “Multiscale Reasoning for Human Physiology.” The agency is seeking input from organizations that can connect human biology from molecules to clinical outcomes in support of military medicine. The focus is on prediction, diagnosis, intervention, and recovery in

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DARPA Seeks Input on Advancing Autonomous Science for Biological Applications RFI

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Overview of the RFI The Defense Advanced Research Projects Agency (DARPA), through its Biological Technology Office (BTO), has released a Request for Information (RFI) titled “Advancing Autonomous Science for Biological Applications” (Special Notice DARPA-SN-26-96). Through this market research effort, DARPA is seeking feedback from industry, academia, and other stakeholders to better understand the current state of

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