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DARPA MARRS to Advance Solid-State Fusion at Room Temperature

DARPA Launches MARRS to Advance Solid-State Fusion at Room Temperature

Broad Agency Announcement: MARRS HR001126S0007 The Defense Advanced Research Projects Agency (DARPA) has released a new Broad Agency Announcement (BAA) under its Defense Sciences Office (DSO) titled Mechanisms for Amplification of Fusion Reaction Rates in Solids (MARRS). Through MARRS, DARPA seeks to explore whether nuclear fusion reactions operating at or near room temperature in solid […]

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DARPA’s Generative Optogenetics (GO) Program

DARPA’s Generative Optogenetics (GO) Program

DARPA-PS-26-10 The Defense Advanced Research Projects Agency (DARPA), through its Biological Technologies Office (BTO), has released a new program solicitation for Generative Optogenetics (GO), a bold, high-risk, high-reward research effort aimed at redefining how genetic information is delivered to living cells. Announced on December 19, 2025, this solicitation reflects DARPA’s continued investment in foundational biological

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DARPA BAA Information Innovation

DARPA I2O Office-Wide BAA Opens the Door for Breakthroughs in Information Innovation

DARPA Broad Agency Announcement HR001126S0001 The Defense Advanced Research Projects Agency (DARPA), through its Information Innovation Office (I2O), has released its FY2026 Office-Wide Broad Agency Announcement (BAA) seeking groundbreaking research that can fundamentally reshape the nation’s capabilities across information science, cybersecurity, artificial intelligence (AI), and complex software systems. This solicitation, HR001126S0001, invites performers to propose

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DARPA smart red cells program

DARPA’s Smart Red Blood Cells Program: Engineering the Future of Human Performance

DARPA-PS-26-02 (Smart Red Blood Cells Program) The Defense Advanced Research Projects Agency (DARPA), through its Biological Technologies Office (BTO), has announced a groundbreaking solicitation titled DARPA-PS-26-02: Smart Red Blood Cells (Smart-RBC) to redefine human performance in extreme environments. This program seeks to leverage advances in synthetic biology and bioengineering to create red blood cells (RBCs)

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DARPA Disruptioneering Program

DARPA’s Disruptioneering Program

DARPA Disruptioneering Program Announcement 25-07 The Defense Advanced Research Projects Agency (DARPA), through its Defense Sciences Office (DSO), has released its latest Disruptioneering Program Announcement (DARPA-PA-25-07). Published on September 30, 2025, this initiative aims to accelerate the agency’s ability to fund and execute high-risk, high-reward scientific research. At its core, the Disruptioneering program establishes a

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DARPA’s Biological Technologies Office Broad Agency Announcement

DARPA BTO Broad Agency Announcement 10.25 The Defense Advanced Research Projects Agency (DARPA), through its Biological Technologies Office (BTO), has released a new Broad Agency Announcement (BAA), HR001126S0003, on October 1, 2025. This solicitation seeks transformative research leveraging biological processes and technologies to enhance warfighter protection and performance. DARPA BTO continues to push the boundaries

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DARPA’s MASH Program: Autonomous Trauma Care for the Battlefield

DARPA-PS-25-34 (2) Medics Autonomously Stopping Hemorrhage (MASH) The Defense Advanced Research Projects Agency (DARPA), through its Biological Technologies Office (BTO), has announced the Medics Autonomously Stopping Hemorrhage (MASH) program (DARPA-PS-25-34). This initiative targets one of the leading causes of preventable battlefield deaths: non-compressible torso hemorrhage (NCTH). With nearly a quarter of combat fatalities in recent

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DARPA NODES

DARPA Launches NODES to Revolutionize Protein Function Prediction

DARPA-PS-25-30 Program Solicitation Network of Optimal Dynamic Energy Signatures (NODES) On July 31, 2025, the Defense Advanced Research Projects Agency (DARPA), through its Biological Technologies Office (BTO), released a new program solicitation titled Network of Optimal Dynamic Energy Signatures (NODES). This initiative seeks to unlock a deeper understanding of protein functions by moving beyond static

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protein moecules

DARPA’s NODES Program to Decode the Protein Universe Through AI and Biophysics

The Defense Advanced Research Projects Agency (DARPA) has launched a new initiative to advance the understanding of protein molecular function based on sequence and structural data. With over 300 million protein sequences and structures cataloged, but only 1% functionally characterized, DARPA’s Network of Optimal Dynamic Energy Signatures (NODES) program seeks to transform our ability to

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Protein sequencing machine

DARPA PROSE Program: Enabling the Next Leap in Protein Sequencing Technology

Program Announcement PROtein SEquencing (PROSE) Microsystems Technology Office The Defense Advanced Research Projects Agency (DARPA), through its Microsystems Technology Office (MTO), has issued a new Program Announcement (DARPA-PA-25-06) for its PROtein SEquencing (PROSE) initiative. This bold program seeks to overcome longstanding challenges in protein sequencing by investing in novel microsystems and signal processing architectures. PROSE

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Cortisol molecule

DARPA’s CoasterChase Initiative

CoasterChase – BIOLOGICAL TECHNOLOGIES OFFICE – HR001125S0014 Targeting Stress from the Inside Out: DARPA’s CoasterChase Initiative The Defense Advanced Research Projects Agency (DARPA) continues to push the boundaries of biomedical technology with the release of its latest Broad Agency Announcement (BAA), HR001125S0014, titled CoasterChase. Issued by DARPA’s Biological Technologies Office (BTO), this program seeks to

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DARPA’s Ag x BTO Special Topic Calls for Agricultural Defense Innovations

DARPA’s Ag x BTO Special Topic Calls for Agricultural Defense Innovations

Special Topic: Ag x BTO To defend against threats to America’s agricultural infrastructure, the Defense Advanced Research Projects Agency (DARPA) has launched a new Special Topic Area (STA) through its Biological Technologies Office (BTO). Known as Ag x BTO, this initiative seeks to catalyze innovative approaches to defending the U.S. agricultural system from chemical, biological,

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