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DARPA Disruptioneering Program

DARPA’s Disruptioneering Program

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DARPA Disruptioneering Program Announcement 25-07 The Defense Advanced Research Projects Agency (DARPA), through its Defense Sciences Office (DSO), has released its latest Disruptioneering Program Announcement (DARPA-PA-25-07). Published on September 30, 2025, this initiative aims to accelerate the agency’s ability to fund and execute high-risk, high-reward scientific research. At its core, the Disruptioneering program establishes a

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DARPA’s Biological Technologies Office Broad Agency Announcement

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DARPA BTO Broad Agency Announcement 10.25 The Defense Advanced Research Projects Agency (DARPA), through its Biological Technologies Office (BTO), has released a new Broad Agency Announcement (BAA), HR001126S0003, on October 1, 2025. This solicitation seeks transformative research leveraging biological processes and technologies to enhance warfighter protection and performance. DARPA BTO continues to push the boundaries

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ARPA-H THRIVE ISO with Amendment 4

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Last Updated: November 17, 2025 Important Update to Timeline and Submission Requirements (Step 2: PowerPoint Presentation Submission Requirements) THRIVE+ISO_Amendment+4 (2) Transforming Genetic Medicine for Rare Diseases: ARPA-H’s THRIVE Initiative The Advanced Research Projects Agency for Health (ARPA-H), through its Health Science Futures Office, has announced the Treating Hereditary Rare diseases with In Vivo precision genetic

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ARPA-H GIVE Initiative to Transform Genetic Medicine Manufacturing

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ARPA-H 4.0_GIVE_ISO_20250925 Revolutionizing Biomanufacturing for Personalized Genetic Medicines The Advanced Research Projects Agency for Health (ARPA-H), through its Scalable Solutions Office (SSO), has released an Innovative Solutions Opening (ISO) titled Genetic Medicines and Individualized Manufacturing for Everyone (GIVE). This bold initiative seeks to accelerate U.S. leadership in biomanufacturing by enabling distributed, on-demand, and individualized production

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Advancing Biodefense Readiness: MTEC and DTRA’s Multi-Topic RPP

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In September 2025, the Medical Technology Enterprise Consortium (MTEC), in partnership with the Defense Threat Reduction Agency (DTRA), announced a new Request for Project Proposals (RPP) aimed at accelerating U.S. biodefense capabilities. The solicitation, “Advancing Biodefense Readiness: On-Demand Biologics, Automated Threat Detection, and Alternatives for Testing Medical Countermeasures in High Containment,” seeks applied prototype solutions

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DARPA’s MASH Program: Autonomous Trauma Care for the Battlefield

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DARPA-PS-25-34 (2) Medics Autonomously Stopping Hemorrhage (MASH) The Defense Advanced Research Projects Agency (DARPA), through its Biological Technologies Office (BTO), has announced the Medics Autonomously Stopping Hemorrhage (MASH) program (DARPA-PS-25-34). This initiative targets one of the leading causes of preventable battlefield deaths: non-compressible torso hemorrhage (NCTH). With nearly a quarter of combat fatalities in recent

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Broad Spectrum Prophylactics for Acetylcholinesterase Inhibitors

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The Medical CBRN Defense Consortium (MCDC), in collaboration with the Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense (JPEO-CBRND), has released a Request for Information (RFI) to assess industry capabilities in developing broad spectrum prophylactic medical countermeasures (MCMs) against acetylcholinesterase (AChE) inhibitors. These inhibitors, chemical agents that can severely impair nervous system

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BARDA Issues New RPP to Advance Smart Manufacturing for Antibodies

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Driving Innovation in Antibody Manufacturing The Biomedical Advanced Research and Development Authority (BARDA) has launched a new Request for Project Proposals (RPP) aimed at transforming the speed, efficiency, and resilience of antibody (Ab) production. Issued under the Biopharmaceutical Manufacturing Preparedness Consortium (BioMaP-Consortium), the initiative seeks to integrate advanced manufacturing technologies into Ab production systems to

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DTRA–MTEC Pre-Announcement for Biodefense Readiness RPP

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MTEC-25-DTRA Pre-Announcement: Advancing Biodefense Readiness The Medical Technology Enterprise Consortium (MTEC), in support of the Defense Threat Reduction Agency (DTRA), has issued a pre-announcement for an upcoming Request for Project Proposals (RPP). This RPP will be aimed at accelerating medical countermeasures (MCMs) and fieldable biosurveillance technologies across the Chemical and Biological Defense Program. In brief,

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BARDA’s mAb “Smart Manufacturing” Opportunity

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Background The Biomedical Advanced Research and Development Authority (BARDA) within the Administration for Strategic Preparedness and Response (ASPR) has released a Draft Statement of Objectives (SOO) for feedback to help refine requirements for the upcoming “Smart Manufacturing” solicitation aiming to support the development of advanced monoclonal antibody (mAb) manufacturing and development techniques. The solicitation’s overarching

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DOE unveils $1B in critical mineral funding

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Introduction The U.S. Department of Energy (DOE) has announced nearly $1 billion in funding to strengthen domestic critical minerals supply chains. This initiative targets mining, processing, and manufacturing technologies for essential materials such as rare earths, battery components, and specialty elements. It represents a major opportunity for companies prepared to advance clean energy, semiconductors, and

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DTRA’s “Plume” RFI for Marine Toxin Aerosol Exposure Models

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Advancing Countermeasures for Marine Toxin Threats The Defense Threat Reduction Agency (DTRA), through its Research and Development Chemical and Biological Technologies Directorate in support of the Joint Science and Technology Office (JSTO), has issued a Request for Information (RFI) titled “Plume”. This initiative seeks information on the capabilities and availability of suitable animal models for

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