ARPA-H

Download the Solicitation Why ARPA-H is Seeking Solutions for Sleep Health The Advanced Research Projects Agency for Health (ARPA-H), through its Proactive Health Office (PHO), has released an Innovative Solutions Opening (ISO) for the Restorative and health-Enhancing Sleep Time (REST) program (ARPA-H-SOL-26-159). REST seeks to fundamentally change how sleep quality is measured, diagnosed, and treated by […]

Download the Solicitation Restoring Brain Function: ARPA-H’s BRAINS Initiative The Advanced Research Projects Agency for Health (ARPA-H) has launched the Brain Repair of Any Injured Neural Structure (BRAINS) initiative to address a major unmet need in neurological care: the lack of effective therapies to replace damaged or degenerated brain tissue and restore lost function. Brain

Download the Solicitation The Advanced Research Projects Agency for Health (ARPA-H), through its Health Science Futures Mission Office, has released a Sources Sought notice titled “Novel and Enhanced Modalities for Optic Nerve Imaging” (ARPA-H-SS-26-157). This request is being issued in support of ARPA-H’s Transplantation of Human Eye Allografts (THEA) program, an ambitious initiative focused on

ARPA-H-SOL-26-155 APPENDIX A: PROGRAM AND TECHNICAL DESCRIPTION The Advanced Research Projects Agency for Health (ARPA-H) has released the Intelligent Generator of Research (IGoR) Innovative Solutions Opening (ISO), a bold initiative designed to fundamentally transform how biomedical research is conducted. Managed through ARPA-H’s Proactive Health Office, the program seeks to address longstanding inefficiencies in scientific discovery

ARPA-H-SOL-26-144_TIGAR ISO ARPA-H’s new Technology InteGrator and AcceleratoR (TIGAR) Innovative Solutions Opening (ISO) is a tightly scoped opportunity for government contractors and their research partners to reshape how complex biologics, tissues, and organs are stored, transported, and deployed at scale. By seeding high-risk, high-impact biopreservation concepts, TIGAR aims to unlock temperature-flexible storage for increasingly large

STOMP_ISO_ARPA-H-SOL-26-152 The Advanced Research Projects Agency for Health (ARPA-H) has released an Innovative Solutions Opening (ISO) for the Systematic Targeting of Microplastics (STOMP) program, signaling a major federal investment in understanding and addressing the health impacts of micro- and nano-plastics (MNPs). As mounting evidence links MNP exposure to a range of adverse health outcomes, ARPA-H

1-CURE_ISO_ARPA-H-SOL-26-147 Cancer remains one of the leading causes of death globally, with existing treatment modalities often limited by cost, accessibility, and effectiveness, particularly for metastatic disease. In response, the Advanced Research Projects Agency for Health (ARPA-H) has released an Innovative Solutions Opening (ISO) under solicitation ARPA-H-SOL-26-147 for the One Comprehensive Universal Radiotherapy for Everyone (1-CURE)

ISO+Amd+1+-+CIRCLE The Advanced Research Projects Agency for Health (ARPA-H), through its Resilient Systems Office (RSO), has released an Innovative Solutions Opening (ISO) titled Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE), ARPA-H-SOL-26-139 . This solicitation reflects ARPA-H’s mandate to pursue bold, high-impact biomedical innovations that can transform patient outcomes at scale. With CIRCLE,

BIOGAMI ISO ARPA-H-SOL-26-149 The Advanced Research Projects Agency for Health (ARPA-H) has released a new Innovative Solutions Opening (ISO) for the BIOmolecular Grammar for protein Aggregation Modulation and Intervention (BIOGAMI) program. Announced under ARPA-H-SOL-26-149, BIOGAMI reflects ARPA-H’s mission to pursue high-risk, high-reward research that can fundamentally transform health outcomes. The program is focused on addressing

ARPA-H-SOL-26-142_ADVOCATE+ISO ARPA-H Launches ADVOCATE to Transform Cardiovascular Care with Agentic AI The Advanced Research Projects Agency for Health (ARPA-H) has released a new Innovative Solutions Opening (ISO), Agentic AI-Enabled Cardiovascular Care Transformation (ADVOCATE), aimed at fundamentally modernizing how chronic cardiovascular disease (CVD) is managed in the United States. Announced by ARPA-H’s Scalable Solutions Office (SSO),