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ARPA-H

HHS Operations During A Government Shutdown

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When the federal government faces a lapse in appropriations, agencies across the Department of Health and Human Services (HHS) must implement contingency plans to sustain critical activities. Both the Advanced Research Projects Agency for Health (ARPA-H) and the Administration for Strategic Preparedness and Response (ASPR), which houses the Biomedical Advanced Research and Development Authority (BARDA), […]

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ARPA-H THRIVE ISO

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ARPA-H THRIVE_ISO_Final_16092025 Transforming Genetic Medicine for Rare Diseases: ARPA-H’s THRIVE Initiative The Advanced Research Projects Agency for Health (ARPA-H), through its Health Science Futures Office, has announced the Treating Hereditary Rare diseases with In Vivo precision genetic mEdicines (THRIVE) Innovative Solutions Opening (ISO) (ARPA-H-SOL-25-122). The initiative represents a bold step toward curative genetic medicines that

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ARPA-H GIVE Initiative to Transform Genetic Medicine Manufacturing

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ARPA-H 4.0_GIVE_ISO_20250925 Revolutionizing Biomanufacturing for Personalized Genetic Medicines The Advanced Research Projects Agency for Health (ARPA-H), through its Scalable Solutions Office (SSO), has released an Innovative Solutions Opening (ISO) titled Genetic Medicines and Individualized Manufacturing for Everyone (GIVE). This bold initiative seeks to accelerate U.S. leadership in biomanufacturing by enabling distributed, on-demand, and individualized production

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ARPA-H Announces the Functional Repair of Neocortical Tissue (FRONT) Program

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Functional Repair of Neocortical Tissue (FRONT) Health Science Futures (HSF) Innovative Solutions Opening (ISO) ARPA-H-SOL-25-120 July 10, 2025 Restoring the Damaged Brain: ARPA-H’s FRONT Program Targets Functional Neocortical Repair The Advanced Research Projects Agency for Health (ARPA-H) has announced an ambitious new program under its Health Science Futures (HSF) office: the Functional Repair of Neocortical

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ARPA-H’s Scalable Solutions ISO

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Mission Office Innovative Solutions Opening (ISO)– ARPA-H-SOL-24-105 – Amendment 02: June 06, 2025 The Advanced Research Projects Agency for Health (ARPA-H) officially released solicitation ARPA-H-SOL-24-105 under its Scalable Solutions Office (SSO), titled Mission Office Innovative Solutions Opening (ISO). This initiative aims to fuel bold, high-impact biomedical and health innovations that tackle persistent barriers in health

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ARPA-H’s Proactive Health Office ISO Amendment 2

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PROACTIVE HEALTH OFFICE – MISSION OFFICE INNOVATIVE SOLUTIONS OPENING (ISO) – ARPA-H-SOL-24-106 – Amendment 02: June 06, 2025 The Advanced Research Projects Agency for Health (ARPA-H) has recently amended the Proactive Health Office (PHO) Innovative Solutions Opening (ISO). The PHO ISO invites novel and disruptive health innovations aimed at extending health spans and improving health

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ARPA-H Resilient Systems ISO

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RESILIENT SYSTEMS OFFICE – MISSION OFFICE INNOVATIVE SOLUTIONS OPENING (ISO) – ARPA-H-SOL-24-103 – Amendment 02: June 06, 2025 The Advanced Research Projects Agency for Health (ARPA-H) has released Amendment 02 of its Innovative Solutions Opening (ISO) under the Resilient Systems Office (RSO), under Solicitation Number ARPA-H-SOL-24-103. a mission-focused solicitation designed to confront systemic challenges across

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ARPA-H Health Science Futures ISO

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Health Science Futures – MISSION OFFICE INNOVATIVE SOLUTIONS OPENING (ISO) ARPA-H-SOL-24-104 – Amendment 02: June 06, 2025 The Advanced Research Projects Agency for Health (ARPA-H) has released Amendment 02 of its Health Science Futures (HSF) Mission Office Innovative Solutions Opening (ISO), under Solicitation Number ARPA-H-SOL-24-104. As part of its mission to catalyze high-risk, high-reward research,

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ARPA-H’s Four Mission Offices Sharpen Their Vision with ISO Amendments

ARPA-H’s Four Mission Offices Sharpen Their Vision with ISO Amendments

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On June 6, 2025, the Advanced Research Projects Agency for Health (ARPA-H) issued Amendment 02 to its four flagship Innovation Solutions Opening (ISO) solicitations: Health Science Futures (HSF), Proactive Health Office (PHO), Resilient Systems Office (RSO), and Scalable Solutions Office (SSO). These ISOs represent the core operational arms of ARPA-H’s mission to fund transformative, high-risk,

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The White House Initiatives

White House Unveils New Initiatives for Critical Medicines and Biological Research Safety

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Promoting Domestic Production of Critical Medicines The White House is pushing to see more state-of-the-art pharmaceutical manufacturing facilities within the United States to strengthen the supply of essential medicines. On May 5, 2025, the President signed an Executive Order titled “Regulatory Relief to Promote Domestic Production of Critical Medicines.” The goal of this order is

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PROSPR program

Proactive Solutions for Prolonging Resilience Opportunity Announcement

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The Foci of PROSPR ARPA-H-SOL-25-125, PROSPR The PROSPR solicitation outlines a comprehensive, multi-year program structured around the development, validation, and deployment of novel health technologies. The program is divided into three primary technical areas (TAs), each addressing a critical component of healthspan extension: TA1 focuses on developing a PROSPR Intrinsic Capacity (IC) score that quantifies

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ARPA-H_Mission Office Innovative Solutions Openings (ISO)

ARPA-H Mission Office Innovative Solutions Openings (ISOs)

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Overview The Advanced Research Projects Agency for Health (ARPA-H) is dedicated to accelerating transformative health solutions by tackling some of the most pressing challenges in biomedical and healthcare innovation. As part of this mission, ARPA-H has launched Mission Office Innovative Solutions Openings (ISOs) that promote the development of health technologies that lie outside of the

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