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ARPA-H Launches SPECTRA Program to Advance Autism Research, Precision Care, and Quality of Life

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The Advanced Research Projects Agency for Health (ARPA-H) has released the Systems for Phenotypic Evaluation, Clinical Trajectories, Response, and Agency (SPECTRA) solicitation, a new Proactive Health Office program focused on improving how autism is understood, assessed, and supported across the lifespan. SPECTRA seeks multidisciplinary research and development efforts that can identify individual developmental and health

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ARPA-H COSMOS Initiative Seeks to Test Whether Space Can Accelerate Regenerative Drug Development

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The Advanced Research Projects Agency for Health (ARPA-H) has released ARPA-H-SOL-26-165, an Innovative Solutions Opening (ISO) for Comprehensive Organ System Modeling in Outer Space (COSMOS). The program will test a consequential hypothesis for the emerging low Earth orbit (LEO) bioeconomy: whether microgravity accelerates aging-related changes in human tissues quickly enough to make autonomous, space based

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ARPA-H UNIQUE: Advancing Quantum Derived Biomedical Imaging

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The Advanced Research Projects Agency for Health (ARPA-H) has released Innovative Solutions Opening (ISO), UNifying Imaging with QUantum Entanglement* (UNIQUE). The program seeks to determine whether quantum derived observables from 511 keV photon pairs including quantum correlations, correlation loss or decoherence, and positronium sensitive interactions that can provide biologically meaningful imaging contrast beyond the anatomical,

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ARPA-H Launches Emerging Health Innovators Initiative for Early-Career Researchers

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The Advanced Research Projects Agency for Health is preparing to launch the Emerging Health Innovators (EHI) Initiative, a new annual funding pathway designed to bring early-career investigators into the ARPA-H innovation model. The upcoming opportunity is intended for researchers and innovators with bold ideas to address healthcare gaps in the United States, including those who

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ARPA-H STREAM Program: A New Federal Push for Safer, Smarter Weed Management

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The Advanced Research Projects Agency for Health (ARPA-H) has launched the Systems for Tracking and Resilience in Efficient Agricultural-input Management (STREAM) program, a new effort focused on reducing herbicide exposure across the food system without making farming less productive or food less affordable. STREAM starts with a practical problem: herbicides remain essential tools for many

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ARPA‑H’s ASCENT‑IBO Initiative: Accelerating Ibogaine Trials For Opioid Use Disorder

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The Advanced Research Projects Agency for Health (ARPA‑H) has released Special Notice ARPA‑H‑SN‑26‑158 for ASCENT‑IBO: Accelerating Safe Clinical Evaluation of Novel Treatments – Ibogaine for Better Outcomes in OUD. This effort sits under the Proactive Health Office (PHO) Innovative Solutions Opening (ISO ARPA‑H‑SOL‑24‑106) and is directly tied to Executive Order 14401, which directs federal agencies

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ARPA-H Releases FASTPASS For Rapid Screening of Medicines

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The Advanced Research Projects Agency for Health (ARPA‑H) has officially launched the Fast Assessment of Solutions, Therapeutics, Pharmaceuticals, and Supplies (FASTPASS) program to tackle a critical, often invisible problem in the U.S. healthcare system: substandard and contaminated medicines slipping through the supply chain. Drug-related morbidity and mortality cost the system an estimated $528 billion per year and

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Coming Soon From ARPA-H: FASTPASS For Rapid Screening of Medicines  

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The Advanced Research Projects Agency for Health (ARPA‑H) is launching the Fast Assessment of Solutions, Therapeutics, Pharmaceuticals, and Supplies (FASTPASS) program to tackle a critical, often invisible problem in the U.S. healthcare system: substandard and contaminated medicines slipping through the supply chain. Drug-related morbidity and mortality cost the system an estimated $528 billion per year and recalls affect the

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ARPA-H’s Special Notice Supports Executive Order on Serious Mental Illness and OUD

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The Advanced Research Projects Agency for Health (ARPA‑H) has released Special Notice ARPA‑H‑SN‑26‑156 under its Proactive Health Office (PHO), focusing on early clinical development of ibogaine for opioid use disorder (OUD).  This Special Notice sits under ARPA‑H’s Proactive Health Office Innovative Solutions Opening (ISO PHO‑SOL‑24‑106), which is an open solicitation for “revolutionary solutions” that do not

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ARPA-H Launches REST to Transform Sleep Through Home-Based Sleep Diagnostics and Treatment

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Download the Solicitation Why ARPA-H is Seeking Solutions for Sleep Health The Advanced Research Projects Agency for Health (ARPA-H), through its Proactive Health Office (PHO), has released an Innovative Solutions Opening (ISO) for the Restorative and health-Enhancing Sleep Time (REST) program (ARPA-H-SOL-26-159). REST seeks to fundamentally change how sleep quality is measured, diagnosed, and treated by

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ARPA-H’s BRAINS Initiative to Advance Functional Brain Tissue Repair

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Download the Solicitation Restoring Brain Function: ARPA-H’s BRAINS Initiative The Advanced Research Projects Agency for Health (ARPA-H) has launched the Brain Repair of Any Injured Neural Structure (BRAINS) initiative to address a major unmet need in neurological care: the lack of effective therapies to replace damaged or degenerated brain tissue and restore lost function. Brain

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ARPA-H’s THEA Program Seeks Breakthrough Optic Nerve Imaging Technologies

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Download the Solicitation The Advanced Research Projects Agency for Health (ARPA-H), through its Health Science Futures Mission Office, has released a Sources Sought notice titled “Novel and Enhanced Modalities for Optic Nerve Imaging” (ARPA-H-SS-26-157). This request is being issued in support of ARPA-H’s Transplantation of Human Eye Allografts (THEA) program, an ambitious initiative focused on

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