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Advancing Biodefense Readiness: MTEC and DTRA’s Multi-Topic RPP

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In September 2025, the Medical Technology Enterprise Consortium (MTEC), in partnership with the Defense Threat Reduction Agency (DTRA), announced a new Request for Project Proposals (RPP) aimed at accelerating U.S. biodefense capabilities. The solicitation, “Advancing Biodefense Readiness: On-Demand Biologics, Automated Threat Detection, and Alternatives for Testing Medical Countermeasures in High Containment,” seeks applied prototype solutions […]

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DTRA–MTEC Pre-Announcement for Biodefense Readiness RPP

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MTEC-25-DTRA Pre-Announcement: Advancing Biodefense Readiness The Medical Technology Enterprise Consortium (MTEC), in support of the Defense Threat Reduction Agency (DTRA), has issued a pre-announcement for an upcoming Request for Project Proposals (RPP). This RPP will be aimed at accelerating medical countermeasures (MCMs) and fieldable biosurveillance technologies across the Chemical and Biological Defense Program. In brief,

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DTRA’s “Plume” RFI for Marine Toxin Aerosol Exposure Models

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Advancing Countermeasures for Marine Toxin Threats The Defense Threat Reduction Agency (DTRA), through its Research and Development Chemical and Biological Technologies Directorate in support of the Joint Science and Technology Office (JSTO), has issued a Request for Information (RFI) titled “Plume”. This initiative seeks information on the capabilities and availability of suitable animal models for

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DTRA RAVEN Program

DTRA’s Reimagining the Next Generation of Biodefense Vaccines

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Reimagining the Next Generation of Biodefense Vaccines: DTRA’s RAVEN Opportunity The Defense Threat Reduction Agency (DTRA), through its Joint Science and Technology Office (JSTO) and the Research and Development-Chem/Bio Medical Vaccines (RD-CBMV) division, has launched the Reimagining Available Vaccines and Envisioning Novelty (RAVEN) initiative. This forward-looking program is designed to modernize the nation’s medical countermeasure

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3d rendered image of highly pathogenic avian influenza

MCDC Announces “Increased Micro Sampling to Monitor Immunological Response” RPP

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The Joint Science and Technology Office (JSTO) within the Defense Threat Reduction Agency (DTRA), has issued a new Request for Prototype Proposals (RPP) through the Medical CBRN Defense Consortium (MCDC). “Increased Micro Sampling to Monitor Immunological Response” (IMMIR) seeks to improve our ability to monitor immune responses to vaccination, which is critical for accelerating vaccine

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digital rendering of antigens

MCDC Releases “Defined Rapid Antigen Identification and Immunogenic Characterization” RPP

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The U.S. Department of Defense (DoD), through the Joint Science and Technology Office (JSTO) Defense Threat Reduction Agency (DTRA), has released a new Request for Prototype Proposals (RPP-25-07) under the Medical CBRN Defense Consortium (MCDC). This Request for Project Proposals, titled “Defined Rapid Antigen Identification and Immunogenic Characterization” (DRAIIC), aims to increase protection against infectious

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Close-up of Medical Ampoule Production Line at Modern Modern Pharmaceutical Factory. Glass Ampoules are being Filled. Medication Manufacturing Process.

DTRA’s RAVEN RFI Seeks Multivalent Vaccine Innovation

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Reimagining the Future of Vaccines: DTRA’s RAVEN RFI The Defense Threat Reduction Agency (DTRA), through its Joint Science and Technology Office (JSTO), has announced a new Request for Information (RFI) under the initiative titled Reimagining Available Vaccines and Envisioning Novelty (RAVEN). This RFI reflects DTRA’s responsibility to prepare the U.S. warfighter for current and emerging

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Chemical Threat Readiness

Advancing Chemical Threat Readiness: The MCDC’s New Call for Prototypes

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Advancing Chemical Threat Readiness: The MCDC’s New Call for Prototypes April 2025 marks another pivotal moment for U.S. defense readiness in chemical and biological threat detection. Through the Medical CBRN Defense Consortium (MCDC), the Army Contracting Command has issued Solicitation RPP-25-04 seeking Enhanced White Papers for a groundbreaking prototype: the Assay Expansion for Chemical Diagnostic

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organophosphorus nerve agents

Project UPREG

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Project UPREG: DTRA’s Push for Enhanced Protection Against Nerve Agents The Defense Threat Reduction Agency’s (DTRA) Chemical and Biological Technologies Department, in its role as the Joint Science and Technology Office (JSTO), has launched Project UPREG, a bold initiative to develop next-generation medical countermeasures against organophosphorus nerve agents (OPNAs). These highly toxic compounds pose a

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handheld diagnostic device

Assay Expansion for Chemical Diagnostic System

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Assay-Expansion-for-Chemical-Diagnostics-System-SOO_Final The Defense Threat Reduction Agency’s Medical Diagnostics Branch (RD-CBMD) is driving innovation with its 2026 solicitation to expand the ChemDx platform. ChemDx is a handheld diagnostic device for rapid detection of chemical threats, such as nerve agents or certain pesticides, in blood from a finger prick. This effort seeks proposals from organizations interested in

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technology to identify novel antigens

DTRA MCDC RAIIC Funding Opportunity

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Final-draft-SOO-RAIIC The Joint Science and Technology Office (JSTO) Defense Threat Reduction Agency (DTRA) has announced an upcoming funding opportunity for members of the Medical CBRN Defense Consortium (MCDC) to develop technologies that can accelerate the identification and immune profile of novel antigens in emerging infectious diseases (EID). JSTO intends to incorporate the final technology into

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compact wearable vaccine monitoring

DTRA Issues Draft SOO for Continual Blood Sampling Technology

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Final-Draft-SOO-IMMIR The Joint Science and Technology Office (JSTO) within the Defense Threat Reduction Agency (DTRA) has announced an upcoming funding opportunity for members of the Medical CBRN Defense Consortium (MCDC). The objective of the IMMIR solicitation is to develop innovative technologies for vaccine monitoring via a compact wearable device that can analyze minute blood samples.

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