Health Science Futures – MISSION OFFICE INNOVATIVE SOLUTIONS OPENING (ISO) ARPA-H-SOL-24-104 – Amendment 03: October 14, 2025 The Advanced Research Projects Agency for Health (ARPA-H) has released Amendment 02 of its Health Science Futures (HSF) Mission Office Innovative Solutions Opening (ISO), under Solicitation Number ARPA-H-SOL-24-104. As part of its mission to catalyze high-risk, high-reward research, […]
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On June 6, 2025, the Advanced Research Projects Agency for Health (ARPA-H) issued Amendment 02 to its four flagship Innovation Solutions Opening (ISO) solicitations: Health Science Futures (HSF), Proactive Health Office (PHO), Resilient Systems Office (RSO), and Scalable Solutions Office (SSO). These ISOs represent the core operational arms of ARPA-H’s mission to fund transformative, high-risk,
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Promoting Domestic Production of Critical Medicines The White House is pushing to see more state-of-the-art pharmaceutical manufacturing facilities within the United States to strengthen the supply of essential medicines. On May 5, 2025, the President signed an Executive Order titled “Regulatory Relief to Promote Domestic Production of Critical Medicines.” The goal of this order is
The Foci of PROSPR ARPA-H-SOL-25-125, PROSPR The PROSPR solicitation outlines a comprehensive, multi-year program structured around the development, validation, and deployment of novel health technologies. The program is divided into three primary technical areas (TAs), each addressing a critical component of healthspan extension: TA1 focuses on developing a PROSPR Intrinsic Capacity (IC) score that quantifies
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Overview The Advanced Research Projects Agency for Health (ARPA-H) is dedicated to accelerating transformative health solutions by tackling some of the most pressing challenges in biomedical and healthcare innovation. As part of this mission, ARPA-H has launched Mission Office Innovative Solutions Openings (ISOs) that promote the development of health technologies that lie outside of the
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RAPID_SOL_25_119_FINAL Overview The Advanced Research Projects Agency for Health (ARPA-H) recently announced the newly approved program for Rare disease AI/ML for Precision Integrated Diagnostics (RAPID). The RAPID program aims to significantly improve outcomes for people with rare diseases by reducing diagnostic delays by ≥50%, decreasing misdiagnosis rates, and expanding access to diagnostics. Beyond benefitting the treatment experience of
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ARPA_H_SOL_25_118_EHI_Solicitation (1) Emerging Health Innovators Solicitation: An Opportunity to Revolutionize Health Innovation The Advanced Research Projects Agency for Health (ARPA-H) has issued the Emerging Health Innovators (EHI) Initiative Solicitation (ARPA-H-SOL-25-118), a groundbreaking funding opportunity aimed at empowering both early-career researchers and community innovators to advance health and biomedical research. Through the EHI Initiative, ARPA-H seeks
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RAPID_Special_Notice ARPA-H’s RAPID Program The Advanced Research Projects Agency for Health (ARPA-H) recently announced the newly approved program for Rare disease AI/ML for Precision Integrated Diagnostics (RAPID). This initiative aims to revolutionize the prolonged diagnostic odyssey faced by millions of rare disease patients worldwide. Utilizing fragmented datasets and state-of-the-art technologies, RAPID aims to democratize access
ARPA-H-SOL-25-125_Special_Notice ARPA-H’s PROSPR Program The Advanced Research Projects Agency for Health (ARPA-H) has announced the PROactive Solutions for Prolonging Resilience (PROSPR) initiative, an ambitious program designed to extend the healthspan of Americans by addressing the underlying causes of age-related health loss. By pioneering innovative interventions that target age-induced health deterioration, ARPA-H aims to revolutionize healthcare
ARPA-H launches groundbreaking funding opportunity The Advancing Clinical Trial Readiness (ACTR) Initiative, spearheaded by ARPA-H’s Resilient Systems Office (RSO), aims to revolutionize clinical trials by developing a decentralized, efficient, and accessible infrastructure. Overview of Solicitation The ACTR Initiative is focused on creating tools, networks, and infrastructure to enable decentralized and on-demand clinical trials. By integrating
ARPA-H-SN-25-119 (1) The Advanced Research Projects Agency for Health (ARPA-H) has launched the Emerging Health Innovators (EHI) Initiative, a transformative funding opportunity aimed at empowering early-career researchers and community-based innovators to revolutionize healthcare. To support this initiative, ARPA-H is holding a virtual Proposer’s Day on January 8th, 2025, from 11AM to 4PM EDT. Overview of
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GLIDE_ISO_ARPA-H-SOL-24-111_Final_29_OCT_2024 Program Overview An estimated 10 million Americans are impacted by primary lymphatic diseases, and lymphatic dysfunction contributes to the pathophysiology of many widespread chronic illnesses. Despite the importance of the lymphatic system in disease, there are currently zero FDA-approved treatments, medical devices, or therapies specifically targeting lymphatic growth and function. To catalyze a future
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