The Advanced Research Projects Agency for Health (ARPA-H) has released Amendment 02 of its Innovative Solutions Opening (ISO) under the Resilient Systems Office (RSO), under Solicitation Number ARPA-H-SOL-24-103. a mission-focused solicitation designed to confront systemic challenges across U.S. healthcare.
As one of several mission office solicitations, this opportunity invites forward-thinking organizations to propose unconventional, high-impact research and development (R&D) projects that could redefine health system resilience by confronting system challenges across U.S. healthcare. The RSO ISO prioritizes bold innovation over incremental advancement and positions itself as a platform to solicit outside-the-box thinking not currently covered under traditional programmatic funding.
Solicitation Goals: Building Robust, Efficient, and Responsive Health Systems
ARPA-H’s RSO ISO targets persistent vulnerabilities in health and public health systems, ranging from chronic disease burden to digital and supply chain infrastructure weaknesses. It aims to catalyze revolutionary systems-level advancements by soliciting proposals that address three primary focus areas:
- System Robustness: Technologies that extend system longevity and ensure peak performance in varied healthcare settings. Innovations might include robust biological systems, secure and efficient digital infrastructure, and socio-technical networks that support continuous access to care and critical data.
- System Efficiency & Integration: Solutions that eliminate systemic inefficiencies through enhanced interoperability, realignment of incentives, and development of user-centric tools to streamline coordination and improve both clinical and research workflows.
- Disruption Mitigation: Agile, anticipatory tools and platforms for detecting and responding to acute disruptions across the healthcare value chain, especially in logistics, supply chains, and emergency response.
Key Dates and Process Timeline
ARPA-H has provided a flexible, rolling framework for submissions under this ISO:
- Solution Summary Submission Deadline: March 5, 2029
- Proposal Deadline: Within 45 calendar days after receiving ARPA-H feedback on Solution Summary
- Q&A Period: Open for the duration of the solicitation via ARPA-H Portal
- Solicitation Procedures: Proposers must first submit a Solution Summary through ARPA-H’s portal and receive written feedback prior to submitting a full proposal. Proposals submitted without this prerequisite will not be reviewed.
Award and Funding Information
This ISO will issue multiple awards under the Other Transactions (OTs) authority, exempt from the Federal Acquisition Regulation (FAR). While specific funding amounts are not pre-set, ARPA-H is seeking projects commensurate with significant technical and organizational ambition.
- Eligible Applicants: Academic institutions, non-profit organizations, for-profit entities, hospitals, community health centers, and non-federal research centers. U.S.-based entities preferred with restrictions on foreign participation.
- Period of Performance: Awards may be made in phases with potential options for extended effort.
Advancing National Health Resilience: Why This Matters
ARPA-H’s Resilient Systems ISO is a call to action to radically rethink the infrastructure and dynamics of health delivery. By funding high-risk, high-reward solutions to address long-standing inefficiencies, this solicitation supports ARPA-H’s broader mission of transforming American healthcare through advanced science and engineering.
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