The Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense (JPEO-CBRND) has released a new Request for Information (RFI) titled “End-to-End Untargeted Genomic Sequencing Workflows Appropriate for Military Use.” This RFI underscores the Department of Defense’s (DoD) growing emphasis on rapid, field-deployable biological threat detection, a critical component of maintaining operational readiness in complex environments.
Overview of the RFI: Building Resilience Through Sequencing Innovation
The RFI seeks information on end-to-end, untargeted genomic sequencing solutions tailored for military users with varying technical expertise. JPEO-CBRND is particularly interested in automated systems that simplify complex sequencing tasks and integrate seamlessly into field operations.
Key focus areas include:
- Genomic Sequencing Workflows: Highly automated sequencing pipelines capable of processing both environmental and clinical samples for untargeted genomic analysis.
- Field-Deployable Bioinformatics Tools: Bioinformatic tools optimized for low-resource settings that can identify genetic engineering indicators and detect biological threats regardless of taxonomy.
- Test and Evaluation (T&E) Infrastructure: Capabilities and technologies that can support government-led testing and validation of untargeted sequencing approaches.
- Protein Toxin Sequencing: Advanced methods for sequencing protein toxins using mobile laboratories or field-deployable platforms.
Responses may include white papers, concept briefs, and technical insights describing the system’s design, integration potential, operational readiness, and sustainment strategies. Ideal submissions will detail past performance, scalability, cost drivers, and potential risks.
Key Dates and Submission Details
Organizations interested in responding should note the following key milestones:
- Response Due Date: Friday, December 19, 2025 through the Joint Enterprise Technology Tool (JETT) portal.
- Industry Day: Tentatively Planned for Q2 FY2026 – JPEO-CBRND will host an Industry Day to engage with respondents and outline potential next steps for technology development and acquisition.
Funding and Program Outlook
Although funding details have not yet been released, responses will guide JPEO-CBRND’s strategy for potential future solicitations or contract awards. The agency anticipates leveraging insights from this RFI to inform investments in technologies that can be integrated into the DoD’s broader biodefense architecture. Respondents demonstrating operational readiness, scalability, and cost-effective sustainment models are expected to be competitive in any subsequent acquisition phase.
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