ARPA-H

BIOGAMI ISO ARPA-H-SOL-26-149 The Advanced Research Projects Agency for Health (ARPA-H) has released a new Innovative Solutions Opening (ISO) for the BIOmolecular Grammar for protein Aggregation Modulation and Intervention (BIOGAMI) program. Announced under ARPA-H-SOL-26-149, BIOGAMI reflects ARPA-H’s mission to pursue high-risk, high-reward research that can fundamentally transform health outcomes. The program is focused on addressing […]

ARPA-H-SOL-26-142_ADVOCATE+ISO ARPA-H Launches ADVOCATE to Transform Cardiovascular Care with Agentic AI The Advanced Research Projects Agency for Health (ARPA-H) has released a new Innovative Solutions Opening (ISO), Agentic AI-Enabled Cardiovascular Care Transformation (ADVOCATE), aimed at fundamentally modernizing how chronic cardiovascular disease (CVD) is managed in the United States. Announced by ARPA-H’s Scalable Solutions Office (SSO),

BOSS_ISO_Final_01Dec2025 The Advanced Research Projects Agency for Health (ARPA-H) has announced a landmark Innovative Solutions Opening (ISO) for the BioStabilization Systems (BoSS) program, an ambitious effort to revolutionize how live cell-based therapies are stabilized, manufactured, and distributed. As outlined in the solicitation, BoSS aims to eliminate the field’s dependence on ultra-cold storage and transport, which

ARPA-H-RFS-EVIDENT-TA-1-3-Exploratory_Clean ARPA-H’s EVIDENT Program Seeks Objective Clinical Endpoints for Rapid-Acting Behavioral Health Treatments (1) Mental and behavioral health disorders, including depression, anxiety, and addiction, affect about half of all Americans, with treatment costs nearing $200 billion annually.  Yet, traditional diagnostics still rely heavily on subjective endpoints that fail to capture the complexity and immediacy of

MOCS_ISO_Amend_+01_20251216 The Advanced Research Projects Agency for Health (ARPA-H) has released a major new Innovative Solutions Opening (ISO) titled Making Obstetric Care Smart (MOCS). This is a national effort to transform maternal and fetal health outcomes through advanced, data-driven technologies. As maternal morbidity and mortality rise across the United States, ARPA-H is calling on innovators

THRIVE+ISO_Amendment_No_1_Tracked_Changes (1) Amendment released for ARPA-H’s THRIVE Initiative The Advanced Research Projects Agency for Health (ARPA-H), through its Health Science Futures Office, released Amendment No. 1 for the Treating Hereditary Rare diseases with In Vivo precision genetic mEdicines (THRIVE) Innovative Solutions Opening (ISO) (ARPA-H-SOL-25-122) on October 17, 2025. The updates focus on changes to the

Last Updated: November 17, 2025 Important Update to Timeline and Submission Requirements (Step 2: PowerPoint Presentation Submission Requirements) THRIVE+ISO_Amendment+4 (2) Transforming Genetic Medicine for Rare Diseases: ARPA-H’s THRIVE Initiative The Advanced Research Projects Agency for Health (ARPA-H), through its Health Science Futures Office, has announced the Treating Hereditary Rare diseases with In Vivo precision genetic

ARPA-H 4.0_GIVE_ISO_20250925 Revolutionizing Biomanufacturing for Personalized Genetic Medicines The Advanced Research Projects Agency for Health (ARPA-H), through its Scalable Solutions Office (SSO), has released an Innovative Solutions Opening (ISO) titled Genetic Medicines and Individualized Manufacturing for Everyone (GIVE). This bold initiative seeks to accelerate U.S. leadership in biomanufacturing by enabling distributed, on-demand, and individualized production