The Advanced Research Projects Agency for Health (ARPA-H) has recently amended the Proactive Health Office (PHO) Innovative Solutions Opening (ISO). The PHO ISO invites novel and disruptive health innovations aimed at extending health spans and improving health outcomes before disease onset. The updates to the PHO ISO reflect ARPA-H’s continued mission to reimagine health science by enabling early detection, preventive interventions, and system-level innovations that empower individuals to lead healthier lives.
Solicitation Goals and Structure
The PHO ISO (Solicitation No. ARPA-H-SOL-24-106) targets transformative ideas that radically improve health outcomes through three focus areas (these are unchanged in Amendment 2):
- Novel prevention and detection tools: includes low/no-cost sensing technologies, scalable early detection of disease, and population-wide health-state monitoring solutions.
- Behavioral interventions to increase health: includes education around and incentives to promote sustained healthy behaviors, advancements to increase human health span even in the absence of disease, and development of novel indicators of pre-disease and disease states.
- System-level health innovations to deliver proactive health: Including new delivery and funding models, predictive health outcome surrogates, and valuation models for public health interventions such as screenings and vaccinations.
ARPA-H is only interested in proposals presenting bold, cutting-edge innovative leaps that are not yet achievable through traditional commercial or academic pathways. All interested parties must first submit a Solution Summary, which ARPA-H will review for novelty and mission alignment. Only after receiving written feedback on the solution summary may proposers submit a full proposal.
Key Dates and Submission Details
ARPA-H has structured this solicitation to remain open long-term, with rolling submissions and feedback opportunities:
- The final closing date is March 5, 2029.
- The Solution Summary submittal is rolling until the ISO closes.
- Proposals are expected to be submitted within 45 calendar days of receiving Solution Summary feedback.
- Awards will be given as Other Transaction Agreements.
- Multiple awards are anticipated.
- Eligibility is open to academia, non-profits, for-profit companies, hospitals, community health centers, and non-federal research entities.
Advancing Health Before Disease Strikes
ARPA-H’s ongoing investment in the PHO ISO presents a unique opportunity for organizations to help prevent disease instead of reacting to it. By focusing on population-level health innovation and bold new methodologies, this solicitation aims to break the mold of traditional healthcare paradigms. The potential impact of funded projects spans from reducing healthcare costs to improving quality of life across all stages of the human lifespan.
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