Biomedical Advanced Research and Development Authority (BARDA) through the Rapid Response Partnership Vehicle (RRPV) initiative released a Request for Project Proposals (RPP) to establish Central Influenza and Emerging Infectious Diseases Vaccine Immunogenicity Laboratory Services to support vaccine development and response to pandemics and emerging infectious diseases.
The RPP addresses the increasing threat of pandemics caused by highly virulent influenza viruses (e.g., A(H5N1), A(H7N9)) and SARS-CoV-2. BARDA’s goal is to maintain readiness for rapid response and vaccine production in the event of a pandemic. The RPP identifies a readiness gap in BARDA’s ability to respond quickly to new strains and aims to partner with laboratories to perform centralized immune assays and support clinical trials for vaccines under FDA regulations.
Evaluation Criteria
Proposals will be evaluated based on their technical approach, relevant experience, qualifications of key personnel, cost realism, and the ability to meet required capabilities. The evaluation will assign confidence ratings to non-cost factors and determine the best value to the government.
Technical Requirements
The document outlines five critical capabilities required for the project:
- Influenza Virus HAI and MN Assays: Qualify and perform assays to support clinical trial endpoint analyses.
- Functional and Neutralizing Antibody Assays: Conduct assays to support immunogenicity analyses.
- Flow Cytometric and ELISpot Assays: Perform assays to support immunogenicity analyses.
- Binding and Enzyme-Inhibition Immunoassays: Conduct assays using ELISA and ELLA.
- Exploratory Assays: Perform novel assays including genome phase display libraries and biolayer interferometry.
Special Considerations
Small business utilization is encouraged to support economic growth and development. Offerors are also encouraged to consider cost sharing to enhance government-performer collaboration.
If your company has considered applying for BARDA funding, your federal funding journey starts here.
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